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Thorough toxicology evaluation revealed no lethal dose in rats receiving up to 20 mg per kg intramuscularly with 14-day observation

tissue homeostasis

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The Boc-protected cystine-1,1′- 13 C was reacted with two equivalents of glycine tert -butyl ester (OtBu) hydrochloride using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride and 1-hydroxybenzotriazole to produce the N and C-protected dipeptidyl (Boc-Cys-Gly-OtBu) disulfide derivative